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As the glycine in position 2 of our analogues prevents the specific DDP-4 cleavage between residues 2 and 3, our attention was turned toward the later

Pancreatitis, though uncommon with an incidence of less than one percent, represents a potentially serious complication that requires immediate medical attention

[1] [2] Marketed under brand names including Ozempic, Wegovy, and Rybelsus, semaglutide works by mimicking the action of the naturally occurring hormone GLP-1, which enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety